Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice. Gracioso Martins AM, Snider DB, Popowski KD, Schuchard KG, Tenorio M, Akunuri S, Wee J, Peters KJ, Jansson A, Shirwaiker R, Cheng K, Freytes DO, Cruse GP. Journal of Controlled Release. (Pubmed) (Article)

The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis. Hedgespeth BA, Snider DB, Bitting KJ, Arthur GK, Smith C and Cruse G. Frontiers in Immunology. (Pubmed) (Article)

Identification of redundancy between human FcεRIβ and MS4A6A proteins points toward additional complex mechanisms for FcεRI trafficking and signaling. Bitting K, Hedgespeth B, Ehrhardt-Humbert LC, Arthur GK, Schubert AG, Bradding P, Tilley SL, Cruse G. Allergy. (Pubmed) (Article)


Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis. Cortes LM, Brodsky D, Chen C, Pridgen T, Odle J, Snider DB, Cruse G, Putikova A, Masuda MY, Doyle AD, Wright BL, Dawson HD, Blikslager A, Dellon ES, Laster SM, Käser T. Frontiers in Allergy. (Pubmed) (Article)

Regulation of Trafficking and Signaling of the High Affinity IgE Receptor by FcεRIβ and the Potential Impact of FcεRIβ Splicing in Allergic Inflammation. Arthur GK, Cruse G. Int J Mol Sci. (Pubmed)

Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms. Snider DB, Arthur GK, Falduto GH, Olivera A, Ehrhardt-Humbert LC, Smith E, Smith C, Metcalfe DD, Cruse G. Molecular Therapy. (Pubmed) (Article)


Identification of an ATP-P2X7-mast cell pathway mediating ozone-induced bronchial hyperresponsiveness. Kong X, Bennett WC, Jania C, Chason K, German Z, Adouli J, Budney SD, Obey BT, van Heusden C, Lazarowski ER, Jaspers I, Randell SH, Hedgespeth BA, Cruse G, Hua X, Schworer SA, Smith GJ, Kelada SNP, and Tilley SL. JCI Insight. (Pubmed)

Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation. Ozpinar EW, Frey AL, Arthur GK, Mora-Navarro C, Biehl A, Snider DB, Cruse G, Freytes DO. Tissue Eng Part A. (Pubmed)

Mast Cell-Biomaterial Interactions and Tissue Repair. Ozpinar EW, Frey ALCruse G, Freytes DO. Tissue Eng Part B Rev. (Pubmed)


Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. Mishra SK, Wheeler JJ, Pitake S, Ding H, Jiang C, Fukuyama T, Paps JS, Ralph P, Coyne J, Parkington M, DeBrecht J, Ehrhardt-Humbert LC, Cruse GP, Bäumer W, Ji RR, Ko MC, Olivry T. Cell Rep. (Pubmed)

The FcεRIβ homologue, MS4A4A, promotes FcεRI signal transduction and store-operated Ca2+ entry in human mast cells. Arthur GK, Ehrhardt-Humbert LC, Snider DB, Jania C, Tilley SL, Metcalfe DD, Cruse G. | Cell Signal. (Pubmed) (Article)

Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles. Chee E, Nandi S, Nellenbach K, Mihalko E, Snider DB, Morrill L, Bond A, Sproul E, Sollinger J, Cruse G, Hoffman M, Brown AC. | J Biomed Mater Res B Appl Biomater. (Pubmed)


Roles for MS4A4 in FcɛRI signal transduction and store-operated calcium entry in human mast cells. Arthur GK and Cruse G. | 

Exon skipping of FcεRIβ for allergic diseases. Arthur GK and Cruse G. | Methods Mol Biol. (Pubmed)


Exon skipping of FcεRIβ eliminates expression of the high affinity IgE receptor in mast cells with therapeutic potential for allergy. Cruse G, Yin Y, Fukuyama T, Desai A, Arthur GK, Bäumer W, Beaven MA, and Metcalfe DD. | Proc Natl Acad Sci USA. (Pubmed)

Immunophenotypic and ultrastructural analysis of mast cells in Hermansky-Pudlak Syndrome Type-1: A possible connection to pulmonary fibrosis. Kirshenbaum AS, Cruse G, Desai A, Bandara G, Leerkes M, Lee CC, Fischer ER, O’Brien KJ, Gochuico BR, Stone K, Gahl WA, and Metcalfe DD. | PLoS One. (Pubmed)

Vibratory urticaria associated with a missense variant in ADGRE2. Boyden SE, Desai A, Cruse G, Young ML, Bolan HC, Scott LM, Eisch AR, Long RD, Lee CCR, Satorius CL, Pakstis AJ, Kidd KK, Kastner DL, Metcalfe DD, and Komarow HD. | N Engl J Med. (Pubmed)

Mast cells in airway diseases and interstitial lung disease. Cruse G, and Bradding P. | Eur J Pharmacol. (Pubmed)


Flow cytometry-based monitoring of mast cell activation. Cruse G, Gilfillan AM, and Smrz D. | Methods Mol Biol. (Pubmed)

The CD20-homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling. Cruse G, Beaven MA, Music S, Bradding P, Gilfillan AM, and Metcalfe DD. | Mol Biol Cell. (Pubmed)


Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms. Cruse G, Metcalfe DD, and Olivera A | Immunol Allergy Clin North Am. (Pubmed)

Rictor negatively regulates FcεRI-induced mast cell degranulation. Smrz D, Cruse G, Beaven MA, Kirshenbaum A, Metcalfe DD, and Gilfillan AM. | J Immunol. (Pubmed)


A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells. Cruse G, Beaven MA, Ashmole I, Bradding P, Gilfillan AM, and Metcalfe DD | Immunity. (Pubmed)

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. Siegel AM, Stone KD, Cruse G, Lawrence MG, Olivera A, Jung MY, Barber JS, Freeman AF, Holland SM, O’Brien M, Jones N, Nelson CG, Wisch LB, Kong HH, Desai A, Farber O, Gilfillan AM, Rivera J, and Milner JD | J Allergy Clin Immunol. (Pubmed)


Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. Ombrello MJ, Remmers EF, Sun G, Freeman AF, Datta S, Torabi-Parizi P, Subramanian N, Bunney TD, Baxendale RW, Martins MS, Romberg N, Komarow H, Aksentijevich I, Kim HS, Ho J, Cruse G, Jung MY, Gilfillan AM, Metcalfe DD, Nelson C, O’Brien M, Wisch L, Stone K, Douek DC, Gandhi C, Wanderer AA, Lee H, Nelson SF, Shianna KV, Cirulli ET, Goldstein DB, Long EO, Moir S, Meffre E, Holland SM, Kastner DL, Katan M, Hoffman HM, and Milner JD | N Engl J Med. (Pubmed)


Functional KCa3.1 K+ channels are required for human fibrocyte migration. Cruse G, Singh S, Duffy SM, Doe C, Saunders R, Brightling CE and Bradding P | J Allergy Clin Immunol(Pubmed)


Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor. Cruse G, Yang W, Duffy SM, Chachi L, Leyland M, Amrani Y and Bradding P | J Allergy Clin Immunol. (Pubmed)

Airway smooth muscle proliferation and survival is not modulated by mast cells. Kaur D, Hollins F, Saunders R, Woodman L, Sutcliffe A, Cruse G, Bradding P and Brightling C | Clin Exp Allergy. (Pubmed)

Activation of human mast cells through platelet activating factor receptor. Kajiwara N, Sasaki T, Bradding P, Cruse G, Sagara H, Ohmori K, Saito H, Ra C and Okayama Y | J Allergy Clin Immunol. (Pubmed)

Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin. Cruse G, Fernandes VE, de Salort J, Pankhania D, Marinas MS, Brewin H, Andrew PW, Bradding P and Kadioglu A | J Immunol. (Pubmed)

A novel FcepsilonRI beta chain truncation regulates human mast cell proliferation and survival. Cruse G, Kaur D, Leyland M and Bradding P | FASEB Journal(Pubmed)


Airway wall geometry in asthma and non-asthmatic eosinophilic bronchitis. Siddiqui S, Gupta S, Cruse G, Haldar P, Entwisle J, McDonald S, Whithers PJ, Hainsworth SV, Coxson HO and Brightling CE | Allergy. (Pubmed)

IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis. Siddiqui S, Cruse G, McKenna S, Monteiro W, Mistry V, Wardlaw A and Brightling C | BMC Pulm Med. (Pubmed)


Mast cells: Biological properties and role in health and allergic diseases. Bradding P, and Cruse G, Barry Kay, Allen Kaplan, Jean Bousquet and Patrick Holt (Eds). Wiley-Blackwell | In Allergy and Allergic Diseases 2nd Edition pp. 217-257. ISBN: 978-1-4051-5720-9.

IgE alone promotes human lung mast cell survival through the autocrine production of IL-6. Cruse G, Cockerill S, and Bradding P | BMC Immunology. (Pubmed)

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: co-operative roles for CADM1, stem cell factor and IL-6. Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, and Bradding P | J Immunol. (Pubmed)

Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration. Duffy SM, Cruse G, Cockerill SL, Brightling CE, and Bradding P | Eur J Immunol. (Pubmed)

Mast cells promote airway smooth muscle cell differentiation via autocrine upregulation of TGF-beta 1. Woodman L, Siddiqui S, Cruse G, Sutcliffe A, Saunders R, Kaur D, Bradding P and Brightling CE | J Immunol(Pubmed)


Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration through the adenosine A2A receptor. Duffy SM, Cruse G, Brightling CE, and Bradding P | Eur J Immunol. (Pubmed)

KCa3.1 Ca2+ Activated K+ Channels Regulate Human Airway Smooth Muscle Proliferation. Shepherd MC, Duffy SM, Harris T, Cruse G, Schuliga M, Brightling CE, Neylon CB, Bradding P, and Stewart AG | Am J Respir Cell Mol Biol(Pubmed)


Functional KCa3.1 K+ channels are required for human lung mast cell migration. Cruse G, Duffy SM, Brightling CE, and Bradding P | Thorax. (Pubmed)


Beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells. Duffy SM, Cruse G, Lawley W, and Bradding P | FASEB Journal. (Pubmed)

Activation of human lung mast cells by monomeric immunoglobulin E. Cruse G, Kaur D, Yang W, Duffy SM, Brightling CE, and Bradding P | Eur Respir J. (Pubmed)


The K+ channel iKCa1 potentiates Ca2+ influx and degranulation in human lung mast cells. Duffy SM, Berger P, Cruse G, Yang W, Bolton SJ, and Bradding P | J Allergy Clin Immunol(Pubmed)