News

Find a list of our news and achievements below:

Cruse Lab research study reporting an innovative therapeutic strategy for mast cell neoplastic diseases published | August 6, 2021

A Cruse Lab study reports the unconventional utility of exon skipping oligonucleotides to introduce a frameshift into mature mRNA for the receptor tyrosine kinase KIT. Gain-of-function mutations in the KIT receptor are associated with mast cell neoplastic diseases. We have utilized “frameshifting” of KIT transcripts in cancerous mast cells to markedly reduce KIT protein expression and function, which results in reduced proliferation and controlled cell death of the cancer cells in vitro. We also demonstrate that this approach reduces tumor growth and spread in pre-clinical in vivo mouse models. Read more about this exciting study in a news story at NC State University, and in the paper published in Molecular Therapy.

Cruse Lab review published | January 21, 2021

A Cruse Lab collaboration with Dr. Donald Freytes on Mast Cell-Biomaterial Interactions and Tissue Repair has been published in Tissue Engineering Part B Reviews.

Cruse Lab collaborative work published | October 1, 2020

A Cruse Lab collaboration with Dr. Donald Freytes on mast cells in dermal extracellular matrix hydrogels (see our research page) has been published in Tissue Engineering Part A.

Cruse Lab collaborative work published | April 8, 2020

A Cruse Lab collaboration with Dr. Santosh Mishra on periostin and itch has been published in Cell Reports.

 

Cruse Lab publishes study identifying a role for MS4A4A in mast cell degranulation | March 30, 2020

Congratulations to Greer Arthur on her publication demonstrating an important role for MS4A4A in IgE-mediated mast cell degranulation and store-operated calcium entry through Orai1. This study published in the journal Cellular Signalling, is an important step forwards for establishing roles for this understudied protein in immunology and a potential association with allergic diseases.

 

 

Cruse Lab collaborative work published | February 26, 2020

A Cruse Lab collaboration with Dr. Ashley Brown’s Advanced Wound Healing Lab on nanosilver composite pNIPAm microgels has been published in the Journal of Biomedical Materials Research.

 

Cruse Lab awarded NIH R01 from NIAID | September 18, 2019

The Cruse Lab has been awarded an R01 grant from NIAID, NIH to study the Regulation of FcεRI function by the MS4A gene cluster! For details about this project see the molecular mechanisms section of our research. We are looking for motivated people with an interest in molecular and mast cell biology to join this project.

 

Congratulations to Lauren | June 29, 2019

After 3 years in the Cruse lab, Lauren is leaving to study in the MD program at Wake Forest medical school. Thank you for all of your hard work over the last 3 years and best of luck in your new career!

 

 

 

Greer’s last day in the lab | September 18, 2018

After 2 years in the Cruse lab, Greer is leaving to join Dr. Thakur as the new communications and program specialist for the Global Health Program at CVM. Best of luck for the future!!

 

 

 

New Publication |  September 2, 2018

Today, we published our methods of exon skipping in mast cells, and the assays we use to examine the responses of mast cells in vitro and in vivo. Find the article here.

 

 

 

 

2018 CMI Symposium | NC State

Congratulations to Jen and Doug for presenting their posters at the 2018 CMI Symposium, hopefully the first of many presentations for their joint work on drug delivery.

 

 

 

 

2018 CMI Symposium | NC State

Congratulations to Ariana for presenting her poster at the 2018 CMI Symposium and winning second prize for her SIRI project!

 

 

 

 

Immunology 2018 | Austin, TX

Congratulations to Greer for presenting her work “Roles for MS4A4 in FcεRI signal transduction and store-operated calcium entry in human mast cells” at the 2018 AAI conference in Austin, TX, and receiving a 2018 AAI Trainee Poster Award!

 

 

Young Scholar Award | CMI, 2018

Congratulations to Greer and Doug for teaming up with Emily Wrona (Freytes Lab) and Greg Krane (Breen Lab) and winning a Young Scholar Award! Together, they put together a proposal for a summer research project as part of the CMI’s SIRI program. With the award, they will receive a summer stipend for an undergraduate student. Project Title: Development of a Three-Dimensional In Vitro Model of Mast Cell Neoplasia.

 

 

CVM Research Forum | September 22, 2017

Greer and Lauren presented their research on MS4A proteins at the 2017 CVM Research Day & Litwack Lecture today. Find out more about this project on our Research page.

 

 

In: Veterinary Medicine News | April 26, 2017

Article: Attacking Allergies at their Source

Dr. Cruse discusses his recent work on antisense oligonucleotides and the IgE receptor, published in PNAS (Pubmed), and the implications for allergic diseases.

 

 

In: Journal of Allergy and Clinical Immunology | February, 2017

Our work on antisense oligonucleotides and the IgE receptor, published in PNAS (Pubmed), featured in JACI’s News Beyond Our Pages feature this month. Read the piece here.

 

 

 

In: World Allergy Organization | December, 2016

We’re really pleased to see that our work on antisense oligonucleotides and the IgE receptor, published in PNAS (Pubmed), featured in WAO’s Editor’s Choice this month.

 

 

New Publication in PNAS |  December 6, 2016

Today, we published the findings of our study that investigated the use of antisense oligonucleotides for eliminating expression of the β-subunit of the high-affinity IgE receptor (FcεRIβ) in mast cells. Read more in the news article for NC State University, and in the article here.

 

In: Medical Xpress | November, 2016

It’s great to see an article about our work on antisense oligonucleotides and the IgE receptor, published in PNAS (Pubmed), on Medical Xpress this month too!

 

In: Science Daily | November, 2016

It’s good to see an article about our PNAS paper (Pubmed) published on Science Daily!